Association of Early Adulthood 25-Year Blood Pressure Trajectories With Cerebral Lesions and Brain Structure in Midlife.

ABSTRACT:

Importance

Midlife elevated blood pressure (BP) is an important risk factor associated with brain structure and function. Little is known about trajectories of BP that modulate this risk.

Objective

To identify BP trajectory patterns from young adulthood to midlife that are associated with brain structure in midlife.

Design, setting, and participants

This cohort study used data of US adults from Coronary Artery Risk Development in Young Adults (CARDIA), a prospective longitudinal study of Black and White men and women (baseline age 18 to 30 years) examined up to 8 times over 30 years (1985-1986 to 2015-2016). There were 885 participants who underwent brain magnetic resonance imaging (MRI) in the 25th or 30th year examinations. Analyses were conducted November 2019 to D

SUBMITTER: Hu YH 

PROVIDER: S-EPMC8914577 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature