Genome-Wide DNA Methylation in Policemen Working in Cities Differing by Major Sources of Air Pollution.

ABSTRACT: DNA methylation is the most studied epigenetic mechanism that regulates gene expression, and it can serve as a useful biomarker of prior environmental exposure and future health outcomes. This study focused on DNA methylation profiles in a human cohort, comprising 125 nonsmoking city policemen (sampled twice), living and working in three localities (Prague, Ostrava and Ceske Budejovice) of the Czech Republic, who spent the majority of their working time outdoors. The main characterization of the localities, differing by major sources of air pollution, was defined by the stationary air pollution monitoring of PM2.5, B[a]P and NO₂. DNA methylation was analyzed by a genome-wide microarray method. No season-specific DNA methylation pattern was discovered; however, we identified 13,6

SUBMITTER: Honkova K 

PROVIDER: S-EPMC8915177 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature