Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3): a multicentre, randomised, blinded-endpoint, comparative effectiveness study of brain tissue oxygen and intracranial pressure monitoring versus intracranial pressure alone.

ABSTRACT:

Introduction

Management of traumatic brain injury (TBI) includes invasive monitoring to prevent secondary brain injuries. Intracranial pressure (ICP) monitor is the main measurement used to that intent but cerebral hypoxia can occur despite normal ICP. This study will assess whether the addition of a brain tissue oxygenation (PbtO₂) monitor prevents more secondary injuries that will translate into improved functional outcome.

Methods and analysis

Multicentre, randomised, blinded-endpoint comparative effectiveness study enrolling 1094 patients with severe TBI monitored with both ICP and PbtO₂. Patients will be randomised to medical management guided by ICP alone (treating team blinded to PbtO₂ values) or both ICP and PbtO₂. Manageme

SUBMITTER: Bernard F 

PROVIDER: S-EPMC8915289 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature