Cohort profile: genomic data for 26 622 individuals from the Canadian Longitudinal Study on Aging (CLSA).

ABSTRACT:

Purpose

The Canadian Longitudinal Study on Aging (CLSA) Comprehensive cohort was established to provide unique opportunities to study the genetic and environmental contributions to human disease as well as ageing process. The aim of this report was to describe the genomic data included in CLSA.

Participants

A total of 26 622 individuals from the CLSA Comprehensive cohort of men and women aged 45-85 recruited between 2010 and 2015 underwent genome-wide genotyping of DNA samples collected from blood. Comprehensive quality control metrics were measured for genetic markers and samples, respectively. The genotypes were imputed to the TOPMed reference panel. Sex chromosome abnormalities were identified by copy number profiling. Classical human leukocyte antigen gene haplotypes wer

SUBMITTER: Forgetta V 

PROVIDER: S-EPMC8915305 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature