Impact of Quantisal^® Oral Fluid Collection Device on Drug Stability.

ABSTRACT: The stability of drugs can affect drug tests and interpretations. A comprehensive study to verify drug stability in Quantisal^® oral fluid (OF) collection device was undertaken in accordance with Australian standard, AS/NZS 4760:2019 (SAI-Global, 2019). The evaluation was performed for the following drugs: (±) amphetamine, (±) methylamphetamine, (±) 3,4-methylenedioxymethylamphetamine (MDMA), (-)Δ9-tetrahydrocannabinol (THC), cocaine, benzoylecgonine, morphine, codeine, and oxycodone. Stability was assessed at four different storage temperatures over seven time points at ±50% cut-off concentrations (Appendix A, Para A4-4.1, AS/NZS 4760:2019) (SAI-Global, 2019). All drugs were found to be significantly more stable at 4 and -20°C, with stability spanning at least 14 days with perce

SUBMITTER: Riggio M 

PROVIDER: S-EPMC8915805 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature