Association of Prenatal Ambient Air Pollution Exposure With Placental Mitochondrial DNA Copy Number, Telomere Length and Preeclampsia.

ABSTRACT: Background: Studies have shown that ambient air pollution is linked to preeclampsia (PE), possibly via generation of oxidative stress in the placenta. Telomere length and mitochondrial DNA copy number (mtDNAcn) are sensitive to oxidative stress damage. Objective: To study the association between prenatal exposure to ambient nitrogen oxides (NO_x, a marker for traffic-related air pollution), and PE, as well as potential mediation effects by placental telomere length and mtDNAcn. Methods: This is a cross-sectional study of 42 preeclamptic and 95 arbitrarily selected normotensive pregnant women with gestational ambient NO_x exposure assessment in southern Scania, Sweden. Hourly concentrations of NO_x were estimated at the residential addresse

SUBMITTER: Mandakh Y 

PROVIDER: S-EPMC8915808 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature