A Low-Serum Culture System for Prolonged in Vitro Toxicology Experiments on a Macrophage System.

ABSTRACT: Immunotoxicology sensu lato comprises not only toxicity toward immune cells, but also biological reactions from immune cells exposed to toxicants, reactions that may have deleterious effects at the organismal level. Within this wide frame, a specific case of interest is represented by the response of macrophages to particulate materials, with the epitome examples of asbestos and crystalline silica. For such toxicants that are both persistent and often encountered in an occupational setting, i.e. at low but repeated doses, there is a need for in vitro systems that can take into account these two parameters. Currently, most in vitro systems are used in an acute exposure mode, i.e., with a single dose and a readout made shortly if not immediately after exposure. We descri

SUBMITTER: Dalzon B 

PROVIDER: S-EPMC8915817 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature