Threshold of Toxicological Concern-An Update for Non-Genotoxic Carcinogens.

ABSTRACT: The Threshold of Toxicological Concern (TTC) concept can be applied to organic compounds with the known chemical structure to derive a threshold for exposure, below which a toxic effect on human health by the compound is not expected. The TTC concept distinguishes between carcinogens that may act as genotoxic and non-genotoxic compounds. A positive prediction of a genotoxic mode of action, either by structural alerts or experimental data, leads to the application of the threshold value for genotoxic compounds. Non-genotoxic substances are assigned to the TTC value of their respective Cramer class, even though it is recognized that they could test positive in a rodent cancer bioassay. This study investigated the applicability of the Cramer classes specifically to provide adequate protection

SUBMITTER: Batke M 

PROVIDER: S-EPMC8915827 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature