Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex.

ABSTRACT: The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous proteins, F-actin, microtubules, and intermediate filaments. Interactions among the cytoskeletal components are important in determining cell structure and in regulating cell functions. For example, F-actin and microtubules work together to control cell shape and polarity, while the subcellular organization and transport of vimentin intermediate filament (VIF) networks depend on their interactions with microtubules. However, it is generally thought that F-actin and VIFs form two coexisting but separate networks that are independent due to observed differences in their spatial distribution and functions. In this paper, we present a closer investigation of both the structural and functional interplay betwee

SUBMITTER: Wu H 

PROVIDER: S-EPMC8915831 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature