An inhibitor of leukotriene-A₄ hydrolase from bat salivary glands facilitates virus infection.

ABSTRACT: SignificanceAn immunosuppressant protein (MTX), which facilitates virus infection by inhibiting leukotriene A₄ hydrolase (LTA₄H) to produce the lipid chemoattractant leukotriene B₄ (LTB₄), was identified and characterized from the submandibular salivary glands of the bat Myotis pilosus. To the best of our knowledge, this is a report of an endogenous LTA₄H inhibitor in animals. MTX was highly concentrated in the bat salivary glands, suggesting a mechanism for the generation of immunological privilege and immune tolerance and providing evidence of viral shedding through oral secretions. Moreover, given that the immunosuppressant MTX selectively inhibited the proinflammatory activity of LTA₄H, without affecting its antii

SUBMITTER: Fang M 

PROVIDER: S-EPMC8915838 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature