Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future.

ABSTRACT: The Threshold of Toxicological Concern (TTC) is a risk assessment tool for evaluating low-level exposure to chemicals with limited toxicological data. A next step in the ongoing development of TTC is to extend this concept further so that it can be applied to internal exposures. This refinement of TTC based on plasma concentrations, referred to as internal TTC (iTTC), attempts to convert the chemical-specific external NOAELs (in mg/kg/day) in the TTC database to an estimated internal exposure. A multi-stakeholder collaboration formed, with the aim of establishing an iTTC suitable for human safety risk assessment. Here, we discuss the advances and future directions for the iTTC project, including: (1) results from the systematic literature search for metabolism and pharmacokinetic data for

SUBMITTER: Ellison CA 

PROVIDER: S-EPMC8915896 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature