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Dual-function AzuCR RNA modulates carbon metabolism.

ABSTRACT: SignificanceWhile most small, regulatory RNAs are thought to be "noncoding," a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete.

SUBMITTER: Raina M 

PROVIDER: S-EPMC8915982 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Dual-function AzuCR RNA modulates carbon metabolism.

Raina Medha M   Aoyama Jordan J JJ   Bhatt Shantanu S   Paul Brian J BJ   Zhang Aixia A   Updegrove Taylor B TB   Miranda-Ríos Juan J   Storz Gisela G  

Proceedings of the National Academy of Sciences of the United States of America 20220303 10

SignificanceWhile most small, regulatory RNAs are thought to be "noncoding," a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete. ...[more]

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