Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination.

ABSTRACT: Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease of the central nervous system (CNS) with a high socioeconomic relevance. The pathophysiology of MS, which is both complex and incompletely understood, is believed to be influenced by various environmental determinants, including diet. Since the 1990s, a correlation between the consumption of bovine milk products and MS prevalence has been debated. Here, we show that C57BL/6 mice immunized with bovine casein developed severe spinal cord pathology, in particular, demyelination, which was associated with the deposition of immunoglobulin G. Furthermore, we observed binding of serum from casein-immunized mice to mouse oligodendrocytes in CNS tissue sections and in culture where casein-specific antibodies induced complement-dep

SUBMITTER: Chunder R 

PROVIDER: S-EPMC8916005 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature