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Human defensin-inspired discovery of peptidomimetic antibiotics.

ABSTRACT: SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.

SUBMITTER: Luo G 

PROVIDER: S-EPMC8916014 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Human defensin-inspired discovery of peptidomimetic antibiotics.

Luo Gan G   Zhang Jue J   Wang HanBin H   Sun YaQi Y   Cheng BaoLi B   Xu ZhiPeng Z   Zhang Yan Y   Li Hui H   Lu WuYuan W   Nemeth Elizabeta E   Ganz Tomas T   Fang XiangMing X  

Proceedings of the National Academy of Sciences of the United States of America 20220301 10

SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria. ...[more]

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