Human defensin-inspired discovery of peptidomimetic antibiotics.

ABSTRACT: SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.

SUBMITTER: Luo G 

PROVIDER: S-EPMC8916014 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature