Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study.

ABSTRACT:

Objective

Drug-resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and surgical outcome are largely unknown. We created a neuroimaging cohort of patients with individually mapped FCDs to determine factors associated with lesion location and predictors of postsurgical outcome.

Methods

The MELD (Multi-centre Epilepsy Lesion Detection) project collated a retrospective cohort of 580 patients with epilepsy attributed to FCD from 20 epilepsy centers worldwide. Magnetic resonance imaging-based maps of individual FCDs with accompanying demographic, clinical, and surgical information were collected. We mapped the distribution of FCDs, exami

SUBMITTER: Wagstyl K 

PROVIDER: S-EPMC8916105 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature