Mitochondrial DNA Variation Correlated With the High Altitude Intolerance in Chinese Young Han Males.

ABSTRACT:

Objective

Acute exposure to hypobaric hypoxia can trigger acute mountain sickness (AMS), while the exact mechanism has not been fully revealed. The role of genetic factors in the susceptibility of various high-altitude diseases has also gained much interest. Previous studies have provided evidence for the link between AMS and certain nuclear genes or mitochondrial haplogroup. The correlation between point mutations of mitochondrial DNA (mtDNA) and AMS was further explored in the present study.

Methods

A total of 84 young Han males residing at low altitude were taken to an elevation of 4,000 m within 40 h. We collected data of their heart rate, blood pressure, peripheral oxygen saturation (SaO₂), and obtained blood samples, at sea level and at high altitude. AMS wa

SUBMITTER: Li Z 

PROVIDER: S-EPMC8916122 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature