Development and validation of prognostic gene signature for basal-like breast cancer and high-grade serous ovarian cancer.

ABSTRACT:

Purpose

Molecular similarities have been reported between basal-like breast cancer (BLBC) and high-grade serous ovarian cancer (HGSOC). To date, there have been no prognostic biomarkers that can provide risk stratification and inform treatment decisions for both BLBC and HGSOC. In this study, we developed a molecular signature for risk stratification in BLBC and further validated this signature in HGSOC.

Methods

RNA-seq data was downloaded from The Cancer Genome Atlas (TCGA) project for 190 BLBC and 314 HGSOC patients. Analyses of differentially expressed genes between recurrent vs. non-recurrent cases were performed using different bioinformatics methods. Gene Signature was established using weighted linear combination of gene expression levels. Their prognostic performance

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8916168 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature