Weighted Blind Source Separation Can Decompose the Frequency Mismatch Response by Deviant Concatenation: An MEG Study.

ABSTRACT: The mismatch response (MMR) is thought to be a neurophysiological measure of novel auditory detection that could serve as a translational biomarker of various neurological diseases. When recorded with electroencephalography (EEG) or magnetoencephalography (MEG), the MMR is traditionally extracted by subtracting the event-related potential/field (ERP/ERF) elicited in response to "deviant" sounds that occur randomly within a train of repetitive "standard" sounds. However, there are several problems with such a subtraction, which include increased noise and the neural adaptation problem. On the basis of the original theory underlying MMR (i.e., the memory-comparison process), the MMR should be present only in deviant epochs. Therefore, we proposed a novel method called weighted-BSS

SUBMITTER: Matsubara T 

PROVIDER: S-EPMC8916481 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature