Distinct Roles of m⁵C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers.

ABSTRACT: RNA methylation has recently emerged as an important category of epigenetic modifications, which plays diverse physiopathological roles in various cancers. Recent studies have confirmed the presence of 5-methylcytosine (m⁵C) modification on mammalian mRNAs, mainly modified by NOP2/Sun RNA methyltransferase family member 2 (NSUN2), but little is known about the underlying functions of m⁵C. Gynecologic cancers are malignancies starting from women's reproductive organs. The prevalence of gynecologic cancers leads to a massive economic burden and public health concern. In this study, we investigated the potential biological functions of NSUN2 in common gynecologic cancers including cervical cancer, ovarian cancer, and endometrial cancer. Remarkably, distinct scenarios wer

SUBMITTER: Wang L 

PROVIDER: S-EPMC8916577 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature