Oxycodone-Related Deaths: The Significance of Pharmacokinetic and Pharmacodynamic Drug Interactions.

ABSTRACT:

Background and objectives

Oxycodone is frequently prescribed as well as detected in postmortem cases. Concurrent use of pharmacodynamically or pharmacokinetically interacting drugs can cause adverse effects or even fatal intoxication. The aims of this study were to investigate differences in prescriptions for and toxicological findings of pharmacodynamically and pharmacokinetically interacting drugs in fatal oxycodone-related intoxications and other causes of death. We also aimed to investigate the differences in prevalence of oxycodone prescriptions, and the detected postmortem oxycodone concentrations between fatal oxycodone-related intoxications and other causes of death.

Methods

Forensic autopsy cases (2012-2018) where oxycodone was identified in femoral blood (n = 1236)

SUBMITTER: Jakobsson G 

PROVIDER: S-EPMC8917044 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature