Glycated albumin and HbA1c as markers of lower extremity disease inUS adults with and without diabetes.

ABSTRACT:

Aim

We evaluated the associations of two biomarkers of hyperglycemia-hemoglobin A1c(HbA1c) and glycated albumin-with lower extremity disease in US adultsoverall and by diabetes status.

Methods

We conducted a cross-sectional study of adult participants aged ≥ 40 years who attended the National Health and Nutrition Examination Survey (NHANES) 1999-2004 (unweighted N = 5,785). We used logistic regression to evaluate the associations of HbA1c and glycated albumin with lower extremity disease: peripheral neuropathy (assessed by monofilament test), peripheral artery disease (assessed by ankle-brachial index), history of foot ulcer, or amputation. All analyses were weighted and accounted for the complex NHANES sample survey design.

Results

The prevalence of lower extremity d

SUBMITTER: Hicks CW 

PROVIDER: S-EPMC8917067 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature