Dataset Information

A randomized study of genetic education versus usual care in tumor profiling for advanced cancer in the ECOG-ACRIN Cancer Research Group (EAQ152).

ABSTRACT:

Background

Enthusiasm for precision oncology may obscure the psychosocial and ethical considerations associated with the implementation of tumor genetic sequencing.

Methods

Patients with advanced cancer undergoing tumor-only genetic sequencing in the National Cancer Institute Molecular Analysis for Therapy Choice (MATCH) trial were randomized to a web-based genetic education intervention or usual care. The primary outcomes were knowledge, anxiety, depression, and cancer-specific distress collected at baseline (T0), posteducation (T1) and after results (T2). Two-sided, 2-sample t tests and univariate and multivariable generalized linear models were used.

Results

Five hundred ninety-four patients (80% from NCI Community Oncology Research Program sites) were randomized to the web intervention (n = 293) or usual care (n = 301) before the receipt of results. Patients in the intervention arm had greater increases in knowledge (P for T1-T0 < .0001; P for T2-T0 = .003), but there were no significant differences in distress outcomes. In unadjusted moderator analyses, there was a decrease in cancer-specific distress among women (T0-T1) in the intervention arm but not among men. Patients with lower health literacy in the intervention arm had greater increases in cancer-specific distress and less decline in general anxiety (T0-T1) and greater increases in depression (T0-T2) in comparison with those receiving usual care.

Conclusions

Web-based genetic education before tumor-only sequencing results increases patient understanding and reduces distress in women. Refinements to the intervention could benefit low-literacy groups and men.

SUBMITTER: Bradbury AR

PROVIDER: S-EPMC8917095 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

A randomized study of genetic education versus usual care in tumor profiling for advanced cancer in the ECOG-ACRIN Cancer Research Group (EAQ152).

Bradbury Angela R AR Lee Ju-Whei JW Gaieski Jill Bennett JB Li Shuli S Gareen Ilana F IF Flaherty Keith T KT Herman Benjamin A BA Domchek Susan M SM DeMichele Angela M AM Maxwell Kara N KN Onitilo Adedayo A AA Virani Shamsuddin S Park SuJung S Faller Bryan A BA Grant Stefan C SC Ramaekers Ryan C RC Behrens Robert J RJ Nambudiri Gopakumar S GS Carlos Ruth C RC Wagner Lynne I LI

Cancer 20211210 7

<h4>Background</h4>Enthusiasm for precision oncology may obscure the psychosocial and ethical considerations associated with the implementation of tumor genetic sequencing.<h4>Methods</h4>Patients with advanced cancer undergoing tumor-only genetic sequencing in the National Cancer Institute Molecular Analysis for Therapy Choice (MATCH) trial were randomized to a web-based genetic education intervention or usual care. The primary outcomes were knowledge, anxiety, depression, and cancer-specific d ...[more]

PMID: 34890045

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Dataset Information

A randomized study of genetic education versus usual care in tumor profiling for advanced cancer in the ECOG-ACRIN Cancer Research Group (EAQ152).

Background

Methods

Results

Conclusions

Publications

A randomized study of genetic education versus usual care in tumor profiling for advanced cancer in the ECOG-ACRIN Cancer Research Group (EAQ152).

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