Dysbiotic change in gastric microbiome and its functional implication in gastric carcinogenesis.

ABSTRACT: Although there is a growing interest in the role of gastric microbiome on the development of gastric cancer, the exact mechanism is largely unknown. We aimed to investigate the changes of gastric microbiome during gastric carcinogenesis, and to predict the functional potentials of the microbiome involved in the cancer development. The gastric microbiome was analyzed using gastric juice samples from 88 prospectively enrolled patients, who were classified into gastritis, gastric adenoma, or early/advanced gastric cancer group. Differences in microbial diversity and composition were analyzed with 16S rRNA gene profiling, using next-generation sequencing method. Metagenomic biomarkers were selected using logistic regression models, based on relative abundances at genus level. We used Tax4Fun t

SUBMITTER: Park JY 

PROVIDER: S-EPMC8917121 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature