Swelling-induced upregulation of miR-141-3p inhibits hepatocyte proliferation.

ABSTRACT:

Background & aims

MicroRNAs (miRNAs) act as a regulatory mechanism on a post-transcriptional level by repressing gene transcription/translation and play a central role in the cellular stress response. Osmotic changes occur in a variety of diseases including liver cirrhosis and hepatic encephalopathy. Changes in cell hydration and alterations of the cellular volume are major regulators of cell function and gene expression. In this study, the modulation of hepatic gene expression in response to hypoosmolarity was studied.

Methods

mRNA analyses of normo- and hypoosmotic perfused rat livers by gene expression arrays were used to identify miRNA and their potential target genes associated with cell swelling preceding cell proliferation. Selected miR-141-3p was also investigated in

SUBMITTER: Bardeck N 

PROVIDER: S-EPMC8917307 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature