Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging.

ABSTRACT:

Background

As we age, the functioning of the human immune system declines. The results of this are increases in morbidity and mortality associated with infectious diseases, cancer, cardiovascular disease, and neurodegenerative disease in elderly individuals, as well as a weakened vaccination response. The aging of the immune system is thought to affect and be affected by the human virome, the collection of all viruses present in an individual. Persistent viral infections, such as those caused by certain herpesviruses, can be present in an individual for long periods of time without any overt pathology, yet are associated with disease in states of compromised immune function. To better understand the effects on human health of such persistent viral infections, we must first understa

SUBMITTER: Autio A 

PROVIDER: S-EPMC8917371 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature