Dexamethasone, Prednisolone, and Methylprednisolone Use and 2-Year Neurodevelopmental Outcomes in Extremely Preterm Infants.

ABSTRACT:

Importance

Practice variability exists in the use of corticosteroids to treat or prevent bronchopulmonary dysplasia in extremely preterm infants, but there is limited information on longer-term impacts.

Objective

To describe the use of corticosteroids in extremely preterm infants and evaluate the association with neurodevelopmental outcomes.

Design, setting, and participants

This cohort study was a secondary analysis of data from the Preterm Erythropoietin Neuroprotection (PENUT) randomized clinical trial, conducted at 19 participating sites and 30 neonatal intensive care units (NICUs) in the US. Inborn infants born between 24 0/7 and 27 6/7 weeks gestational age between December 2013 and September 2016 were included in analysis. Data analysis was conducted between Fe

SUBMITTER: Puia-Dumitrescu M 

PROVIDER: S-EPMC8917427 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature