Highly sensitive near-infrared SERS nanoprobes for in vivo imaging using gold-assembled silica nanoparticles with controllable nanogaps.

ABSTRACT:

Background

To take advantages, such as multiplex capacity, non-photobleaching property, and high sensitivity, of surface-enhanced Raman scattering (SERS)-based in vivo imaging, development of highly enhanced SERS nanoprobes in near-infrared (NIR) region is needed. A well-controlled morphology and biocompatibility are essential features of NIR SERS nanoprobes. Gold (Au)-assembled nanostructures with controllable nanogaps with highly enhanced SERS signals within multiple hotspots could be a breakthrough.

Results

Au-assembled silica (SiO₂) nanoparticles (NPs) (SiO₂@Au@Au NPs) as NIR SERS nanoprobes are synthesized using the seed-mediated growth method. SiO₂@Au@Au NPs using six different sizes of Au NPs (SiO₂@Au@Au₅₀-SiO

SUBMITTER: Bock S 

PROVIDER: S-EPMC8917682 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature