Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m⁶A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression.

ABSTRACT:

Background

Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously showed that miR-100 and miR-125b, embedded within the third intron of the ncRNA host gene MIR100HG, confer resistance to cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, in colorectal cancer (CRC). However, whether the MIR100HG transcript itself has a role in cetuximab resistance or EMT is unknown.

Methods

The correlation between MIR100HG and EMT was analyzed by curating public CRC data repositories. The biological roles of MIR100HG in EMT, metastasis and cetuximab resistance in CRC were determined both in vitro and in vivo. The expression patterns of MIR100HG, hnRNPA2B1 a

SUBMITTER: Liu H 

PROVIDER: S-EPMC8917698 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature