Platinum prodrug nanoparticles inhibiting tumor recurrence and metastasis by concurrent chemoradiotherapy.

ABSTRACT:

Background

Although concurrent chemoradiotherapy (CRT), as one of the most effective antineoplastic therapies in clinic, can successfully inhibit the growth of tumor cells, a risk of developing secondary tumor is still an insurmountable barrier in clinical practice.

Results

Herein, a new platinum prodrug composed of tannic acid (TA) and Pt²⁺ (TA-Pt) complex film was synthesized on the surface of Fe₂O₃ nanoparticles (NPs) with excellent stability and biocompatibility for enhanced CRT. In this system, TA-Pt complex could respond to the tumor acidic microenvironment and damage the DNA of tumor cells. Moreover, the internal iron core not only improved the effect of subsequent radiotherapy (RT), but also disrupted the iron balance in cells, induci

SUBMITTER: Jiang W 

PROVIDER: S-EPMC8917711 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature