Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis.

ABSTRACT:

Background

Temperature control with target temperature management (TTM) after cardiac arrest has been endorsed by expert societies and adopted in international clinical practice guidelines but recent evidence challenges the use of hypothermic TTM.

Methods

Systematic review and Bayesian meta-analysis of clinical trials on adult survivors from cardiac arrest undergoing TTM for at least 12 h comparing TTM versus no TTM or with a separation > 2 °C between intervention and control groups using the PubMed/MEDLINE, EMBASE, CENTRAL databases from inception to 1 September 2021 (PROSPERO CRD42021248140). All randomised and quasi-randomised controlled trials were considered. The risk ratio and 95% confidence interval for death (primary outcome) and unfavourable neurological recovery (s

SUBMITTER: Aneman A 

PROVIDER: S-EPMC8917746 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature