Chromatin accessibility profiling identifies evolutionary conserved loci in activated human satellite cells.

ABSTRACT: Satellite cells represent the main myogenic population accounting for skeletal muscle homeostasis and regeneration. While our knowledge of the signaling pathways controlling satellite cell regenerative capability is increasing, the underlying epigenetic mechanisms are still not clear, especially in the case of human satellite cells. Here, by performing chromatin accessibility profiling (ATAC-seq) in samples isolated from human and murine muscles, we investigated the changes in the epigenetic landscape occurring during the transition from activated satellite cells to myoblasts. Our analysis identifies a compendium of putative regulatory elements defining human activated satellite cells and myoblasts, respectively. A subset of these differentially accessible loci is shared by both murine and

SUBMITTER: Chow LS 

PROVIDER: S-EPMC8917817 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature