Decreased Activated CD4⁺ T Cell Repertoire Diversity After Antiretroviral Therapy in HIV-1/HCV Coinfection Correlates with CD4⁺ T Cell Recovery.

ABSTRACT: Dysfunctional immune activation accumulates during chronic viral infection and contributes to disease pathogenesis. In HIV-1, immune activation is exacerbated by concurrent infection with hepatitis C virus (HCV), accelerating depletion of CD4⁺ T cells. HIV-1 suppression with antiretroviral therapy (ART) generally reconstitutes CD4⁺ T cell counts, while also reducing the proportion that is activated. Whether this immune reconstitution also reduces the complexity of the CD4⁺ T cell population is unknown. We sought to characterize the relationship between activated CD4⁺ T cell repertoire diversity and immune reconstitution following ART in HIV-1/HCV coinfection. We extracted T cell receptor (TCR) sequences from RNA sequencing data obtained from acti

SUBMITTER: Skinner NE 

PROVIDER: S-EPMC8917883 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature