Mining Clinical Data for Novel Posttraumatic Stress Disorder Medications.

ABSTRACT:

Background

Despite the prevalence and negative impact of posttraumatic stress disorder (PTSD), there are few medications approved by the U.S. Food and Drug Administration for treatment, and approved medications do not work well enough. We leveraged large-scale electronic health record data to identify existing medications that may be repurposed as PTSD treatments.

Methods

We constructed a mechanistic tree of all Food and Drug Administration-approved medications and used the tree-based scan statistic to identify medications associated with greater than expected levels of clinically meaningful improvement in PTSD symptoms using electronic health record data from the U.S. Department of Veterans Affairs. Our cohort included patients with a diagnosis of PTSD who had repeated symp

SUBMITTER: Shiner B 

PROVIDER: S-EPMC8918007 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature