Parallel processing of sensory cue and spatial information in the dentate gyrus.

ABSTRACT: During exploration, animals form an internal map of an environment by combining information about landmarks and the animal's movement, a process that depends on the hippocampus. The dentate gyrus (DG) is the first stage of the hippocampal circuit where self-motion ("where") and sensory cue information ("what") are integrated, but it remains unknown how DG neurons encode this information during cognitive map formation. Using two-photon calcium imaging in mice running on a treadmill along with online cue manipulation, we identify robust sensory cue responses in DG granule cells. Cue cell responses are stable, stimulus-specific, and accompanied by inhibition of nearby neurons. This demonstrates the existence of "cue cells" in addition to better characterized "place cells" in the DG. We hypoth

SUBMITTER: Tuncdemir SN 

PROVIDER: S-EPMC8918037 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature