Circ_0000228 Promotes Cervical Cancer Progression via Regulating miR-337-3p /TGFBR1 Axis.

ABSTRACT:

Objective

This study aims to investigate the biological function of circular RNA (circRNA) circ_0000228 in the cervical cancer (CC).

Materials and methods

In this experimental study, the GSE113696 dataset was downloaded from the Gene Expression Omnibus (GEO). GEO2R was employed to obtain differentially expressed circRNA between CC tissues and matched paracancerous tissues. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were employed to detect circ_0000228, microRNA-337-3p (miR-337-3p ) and transforming growth factor, beta receptor I (TGFBR1) expression levels in the CC tissues and cells. Following gain-of-function and loss-of-function models establishment, CCK-8 and BrdU tests were conducted to examine cell proliferati

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8918268 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature