Neurological Instability in Ischemic Stroke: Relation with Outcome, Latency Time, and Molecular Markers.

ABSTRACT: The National Institutes of Health Stroke Scale (NIHSS) is commonly used to evaluate stroke neurological deficits and to predict the patient's outcome. Neurological instability (NI), defined as the variation of the NIHSS in the first 48 h, is a simple clinical metric that reflects dynamic changes in the area of the brain affected by the ischemia. We hypothesize that NI may represent areas of cerebral instability known as penumbra, which could expand or reduce brain injury and its associated neurological sequels. In this work, our aim was to analyze the association of NI with the functional outcome at 3 months and to study clinical biomarkers associated to NI as surrogate biomarkers of ischemic and inflammatory penumbrae in ischemic stroke (IS) patients. We included 663 IS patients in a retr

SUBMITTER: Iglesias-Rey R 

PROVIDER: S-EPMC8918467 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature