Regulatory B Cells Are Decreased and Functionally Impaired in Myasthenia Gravis Patients.

ABSTRACT: Myasthenia gravis (MG) is an autoimmune disease mediated by B cells secreting autoantibodies. Regulatory B (Breg) cells confirmed to have an immunosuppressive function play an important role in many autoimmune diseases. However, what about the changes in Breg cells in the thymus and peripheral blood of MG patients? The changes in the proportion of Breg cells in the peripheral blood of 41 MG patients without any drug treatment and 30 healthy controls were detected by flow cytometry. We found that the proportions of CD19⁺ IL-10⁺ cells and CD19⁺CD24^hiCD38^hi cell subsets in MG patients were significantly lower than those in healthy controls. Then, we detected the proportion of CD19⁺ IL-10⁺ cells in thymus tissues of 1

SUBMITTER: Lin Y 

PROVIDER: S-EPMC8918563 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature