The Association Between Alveolar Dead Space Fraction and Mortality in Pediatric Acute Respiratory Distress Syndrome: A Prospective Cohort Study.

ABSTRACT:

Background

Alveolar dead-space fraction (AVDSF), the volume of alveolar gas that does not participate in gas exchange, has been reported to predict mortality and morbidity in adults with acute respiratory distress syndrome (ARDS). This study aims to characterize AVDSF in patients with pediatric ARDS (PARDS), to determine its association with clinical outcomes and examine the validity of a previously studied cutoff (AVDSF > 0.25).

Methods

This was a prospective cohort study performed in the setting of a lung protective mechanical ventilation protocol. AVDSF was calculated by the equation: AVDSF = [partial pressure of arterial carbon dioxide (P_aCO₂) - end tidal carbon dioxide (etCO₂)]/P_aCO₂. Receiver operating curve and Yo

SUBMITTER: Oh SB 

PROVIDER: S-EPMC8918668 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature