Accelerated Muscle Deoxygenation in Aerobically Fit Subjects During Exhaustive Exercise Is Associated With the ACE Insertion Allele.

ABSTRACT:

Introduction

The insertion/deletion (I/D) polymorphism in the gene for the major regulator of vascular tone, angiotensin-converting enzyme-insertion/deletion (ACE-I/D) affects muscle capillarization and mitochondrial biogenesis with endurance training. We tested whether changes of leg muscle oxygen saturation (SmO₂) during exhaustive exercise and recovery would depend on the aerobic fitness status and the ACE I/D polymorphism.

Methods

In total, 34 healthy subjects (age: 31.8 ± 10.2 years, 17 male, 17 female) performed an incremental exercise test to exhaustion. SmO₂ in musculus vastus lateralis (VAS) and musculus gastrocnemius (GAS) was recorded with near-IR spectroscopy. Effects of the aerobic fitness status (based on a VO_2peak cutoff

SUBMITTER: Gasser B 

PROVIDER: S-EPMC8918772 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature