Osteoblasts pattern endothelium and somatosensory axons during zebrafish caudal fin organogenesis.

ABSTRACT: Skeletal elements frequently associate with vasculature and somatosensory nerves, which regulate bone development and homeostasis. However, the deep, internal location of bones in many vertebrates has limited in vivo exploration of the neurovascular-bone relationship. Here, we use the zebrafish caudal fin, an optically accessible organ formed of repeating bony ray skeletal units, to determine the cellular relationship between nerves, bones and endothelium. In adult zebrafish, we establish the presence of somatosensory axons running through the inside of the bony fin rays, juxtaposed with osteoblasts on the inner hemiray surface. During development we show that the caudal fin progresses through sequential stages of endothelial plexus formation, bony ray addition, ray innervation and endothe

SUBMITTER: Bump RG 

PROVIDER: S-EPMC8918783 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature