Ontology highlight
ABSTRACT:
SUBMITTER: Cote JL
PROVIDER: S-EPMC8918807 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Cote Jessica L JL Vander Paul B PB Ellis Michael M Cline Joel M JM Svezhova Nadezhda N Doche Michael E ME Maures Travis J TJ Choudhury Tahrim A TA Kong Seongbae S Klaft Olivia G J OGJ Joe Ray M RM Argetsinger Lawrence S LS Carter-Su Christin C
Journal of cell science 20220210 3
The adapter protein SH2B1 is recruited to neurotrophin receptors, including TrkB (also known as NTRK2), the receptor for brain-derived neurotrophic factor (BDNF). Herein, we demonstrate that the four alternatively spliced isoforms of SH2B1 (SH2B1α-SH2B1δ) are important determinants of neuronal architecture and neurotrophin-induced gene expression. Primary hippocampal neurons from Sh2b1-/- [knockout (KO)] mice exhibit decreased neurite complexity and length, and BDNF-induced expression of the syn ...[more]