Role of the environment in transmission of Gram-negative bacteria in two consecutive outbreaks in a haematology-oncology department.

ABSTRACT: In 2019-2020, two subsequent outbreaks caused by phenotypically identical ESBL-producing Enterobacter cloacae and multi-drug-resistant (MDR) Pseudomonas putida were detected in respectively 15 and 9 patients of the haematology-oncology department. Both bacterial species were resistant to piperacillin-tazobactam, used empirically in (neutropenic) sepsis in our hospital, and ciprofloxacin, used prophylactically in selective digestive decontamination for haematology patients. The E. cloacae outbreak was identified in clinical cultures of blood and urine. Despite intensified infection control measures, new cases were found in weekly point-prevalence screening cultures. Environmental samples of sinks and shower drains appeared positive in 18.1%. To diminish the environmenta

SUBMITTER: van der Zwet WC 

PROVIDER: S-EPMC8918851 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature