Physical activity end-points in trials of chronic respiratory diseases: summary of evidence.

ABSTRACT: Physical activity contributes to improving respiratory symptoms. However, validated end-points are few, and there is limited consensus about what is a clinically meaningful improvement for patients. This review summarises the evidence to date on the range of physical activity end-points used in COPD, asthma and idiopathic pulmonary fibrosis (IPF) whilst evaluating their appropriateness as end-points in trials and their relation to patients' everyday life. Trials reporting physical activity end-points were collected using Citeline's database Trialtrove; this was supplemented by searches in PubMed. The daily-patient-reported outcome (PRO)active and clinical visit-PROactive physical activity composite end-points appeared superior at capturing the full experience of physical activity in patien

SUBMITTER: Rist C 

PROVIDER: S-EPMC8918933 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature