Ecological Processes Shaping Microbiomes of Extremely Low Birthweight Infants.

ABSTRACT: The human microbiome has been implicated in affecting health outcomes in premature infants, but the ecological processes governing early life microbiome assembly remain poorly understood. Here, we investigated microbial community assembly and dynamics in extremely low birth weight infants (ELBWI) over the first 2 weeks of life. We profiled the gut, oral cavity and skin microbiomes over time using 16S rRNA gene amplicon sequencing and evaluated the ecological forces shaping these microbiomes. Though microbiomes at all three body sites were characterized by compositional instability over time and had low body-site specificity (PERMANOVA, r ² = 0.09, p = 0.001), they could nonetheless be clustered into four discrete community states. Despite the volatility of these co

SUBMITTER: Zioutis C 

PROVIDER: S-EPMC8919028 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature