A large-scale investigation of white matter microstructural associations with reading ability.

ABSTRACT: Reading involves the functioning of a widely distributed brain network, and white matter tracts are responsible for transmitting information between constituent network nodes. Several studies have analyzed fiber bundle microstructural properties to shed insights into the neural basis of reading abilities and disabilities. Findings have been inconsistent, potentially due to small sample sizes and varying methodology. To address this, we analyzed a large data set of 686 children ages 5-18 using state-of-the-art neuroimaging acquisitions and processing techniques. We searched for associations between fractional anisotropy (FA) and single-word and single-nonword reading skills in children with diverse reading abilities across multiple tracts previously thought to contribute to reading. We also

SUBMITTER: Meisler SL 

PROVIDER: S-EPMC8919267 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature