Myo-inositol nutritional supplement for prevention of gestational diabetes (EMmY): a randomised, placebo-controlled, double-blind pilot trial with nested qualitative study.

ABSTRACT:

Objectives

To determine the feasibility and acceptability of conducting a randomised trial on the effects of myo-inositol in preventing gestational diabetes in high-risk pregnant women.

Design

A multicentre, double-blind, placebo-controlled, pilot randomised trial with nested qualitative evaluation.

Setting

Five inner city UK National Health Service hospitals PARTICIPANTS: Multiethnic pregnant women at 12⁺⁰ and 15⁺⁶ weeks' gestation with risk factors for gestational diabetes.

Interventions

2 g of myo-inositol or placebo, both included 200 µg folic acid, twice daily until delivery.

Primary outcome measures

Rates of recruitment, randomisation, adherence and follow-up.

Secondary outcome measures

Glycaemic indices (including homo

SUBMITTER: Amaefule CE 

PROVIDER: S-EPMC8919454 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature