Integrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis.

ABSTRACT:

Background

Sepsis is defined as a systemic inflammatory response to microbial infections with multiple organ dysfunction. This study analysed untargeted metabolomics combined with proteomics of serum from patients with sepsis to reveal the underlying pathological mechanisms involved in sepsis.

Methods

A total of 63 patients with sepsis and 43 normal controls were enrolled from a prospective multicentre cohort. The biological functions of the metabolome were assessed by coexpression network analysis. A molecular network based on metabolomics and proteomics data was constructed to investigate the key molecules.

Results

Untargeted metabolomics analysis revealed widespread dysregulation of amino acid metabolism, which regulates inflammation and immunity, in patients with

SUBMITTER: Chen Q 

PROVIDER: S-EPMC8919526 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature