Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial.

ABSTRACT:

Background

The gut microbiota has been suggested to play a significant role in the development of overweight and obesity. However, the effects of calorie restriction on gut microbiota of overweight and obese adults, especially over longer durations, are largely unexplored.

Methods

Here, we longitudinally analyzed the effects of intermittent calorie restriction (ICR) operationalized as the 5:2 diet versus continuous calorie restriction (CCR) on fecal microbiota of 147 overweight or obese adults in a 50-week parallel-arm randomized controlled trial, the HELENA Trial. The primary outcome of the trial was the differential effects of ICR versus CCR on gene expression in subcutaneous adipose tissue. Changes in the gut microbiome, which are the focus of this publication, were defin

SUBMITTER: Sowah SA 

PROVIDER: S-EPMC8919571 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature