Parsimonious Clone Tree Integration in cancer.

ABSTRACT:

Background

Every tumor is composed of heterogeneous clones, each corresponding to a distinct subpopulation of cells that accumulated different types of somatic mutations, ranging from single-nucleotide variants (SNVs) to copy-number aberrations (CNAs). As the analysis of this intra-tumor heterogeneity has important clinical applications, several computational methods have been introduced to identify clones from DNA sequencing data. However, due to technological and methodological limitations, current analyses are restricted to identifying tumor clones only based on either SNVs or CNAs, preventing a comprehensive characterization of a tumor's clonal composition.

Results

To overcome these challenges, we formulate the identification of clones in terms of both SNVs and CNAs as a

SUBMITTER: Sashittal P 

PROVIDER: S-EPMC8919608 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature