METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression.

ABSTRACT:

Background

N6-methyladenosine (m6A) RNA methylation and its methyltransferase METTL3 have been widely reported to be involved in different cancers by regulating RNA metabolism and function. Here, we aimed to explore the biological function and clinical significance of m6A modification and METTL3 in head and neck squamous cell carcinoma (HNSCC).

Methods

The prognostic value of METTL3 expression was evaluated using tissue microarray and immunohistochemical staining analyses in a human HNSCC cohort. The biological role and mechanism of METTL3 in HNSCC tumour growth, metastasis and angiogenesis were determined in vitro and in vivo.

Results

M6A levels and METTL3 expressions in HNSCC tissues were significantly increased compared with paired adjacent tissues. Meanwhile, METT

SUBMITTER: Guo YQ 

PROVIDER: S-EPMC8919647 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature